For people with diabetes, high blood -sugar can damage blood glasses and nerves, causing chronic injuries that remain open for months. But a new gel-based treatment could massively speed up the healing process for people with diabetes, allowing injuries to close in just days, according to a new study.
The new treatment is aimed at thrombospin-1 (TSP-1), a protein that prevents the growth of new blood vessels, a core step in the healing process. Target this protein has increased new formation of blood vessels in human endothelial cells and in diabetic mouse models, leading to a considerable injury -closure in less than two weeks. A team of researchers from various institutes in China revealed the new technology in a study published in the newspaper Burns & Trauma.
“Our results demonstrate the power to combine advanced engineering with molecular biology. Targeting TSP-1 with MIR-221OE-SEVs encapsulated in Gelma, we not only improved endothelial cell function, but also ensured ongoing and local therapy of the Chinese level of Chinese plan, said that the Chinese plan said to the fourth. Statement.
Diabetic injuries have increased levels of TSP-1 in endothelial cells, the cells that align blood vessels, according to previous studies. TSP-1 prevents their ability to share and go where they have to go. The study researchers have developed a way to reduce TSP-1 levels.
The technology uses small extracellular vesicles (SEVs) -deen membrane linked bags usually released from cells loaded with MiR-221-3P, micrororna that prevents the production of TSP-1 in endothelial cells.
The researchers encapsulated these SEVs in Hydrogel, which mimics the extracellular environment and provide an ongoing, controlled release of MiR-221-3P at the injury site. In diabetic mouse models, the gel significantly accelerated healing, leading to a 90% injured closure -rate within 12 days – compared to only 20% in untreated mice during the same period.
The following steps are to bring the new gel into clinical trials, according to the authors. “This advance could revolutionize as we approach diabetic injured care, with the possibility of improving the quality of life of patients significantly,” Shen said in a statement.
