Some people who use drugs as an Ozmpym have noticed a surprising but welcome side effect: they Drink less.
Paper Posted on Wednesday It offers the strongest evidence that it is more than just an anecdote or placebo effect: found that semaglutide, a substance in the eager and the drug of weight loss could actually help reduce the appetite for alcohol. This is the first randomized controlled study on the consumption of semaglutide and alcohol.
The study followed by 48 adults who met the criteria for disorder of alcohol use, which is often characterized by difficulty controlling alcohol consumption. Half of the patients took low doses of semaglutide and half received placebo. Participants spent two hours in a laboratory room supplied with their preferred alcoholic beverages – once before they started taking the drug, and once. People in the study also reported how much every day for nine weeks.
Those who took Semaglutid still drank as often as those who took placebo. In the second month of the study, however, people who use semaglutid on average sailed almost 30 percent less on days when they consumed alcohol – compared to an average reduction in about two percent in a placebo group. People who took the semaglutid also reported less days of drinking than those on placebo and said their desires for alcohol were reduced.
The effects on alcohol consumption were greater than scientists were expected, given the previous data on other drugs to use alcohol use, said Christian Hendershot, clinical research director at the University of Southern California Institute for Addiction Science and the main author in the study.
There has been so many drug research such as semaglutide and alcohol, “You can’t even keep up,” said W. Kyle Simmons, professor of pharmacology and physiology at Oklahoma State University, currently conducting a court on the effects of drugs on the effects of drugs alcohol.
One such document published last month examined records from More than two million people With a diabetes who received medical care from the US Department of Veterans. The contribution found that those who used a drug in the same class of medicinal products, because the Ochemip had a lower risk of disorders of the use of addictive substances, including alcohol use than people who took other diabetes drugs.
And last May a study investigating a large database of medical records found that people with disorder of alcohol use and obesity or diabetes 2. less likely to relapse.
Joseph Schacht, Associate Professor of Psychiatry at the University of Colorado, who also conducts a study on semaglutide and alcohol desires, said scientists still did not determine how the drug could reduce the desire to drink.
However, the anterior hypothesis is that the drug affects the paths of remuneration in the brain. Like drugs, food can cause less attractive food, it can also cause alcohol to attract less. In addition Animals They have shown that drug -related drugs inhibit the release of dopamine associated with alcohol exposure, which theoretically can reduce the motivation for drinking.
“I think it will change people who fight their ability to control their drink, potentially people who can control their drinks,” Schacht.
Scientists theorized that the effect could spread to a number of addictive behavior. This could explain why among a small subset of people in a study who smoked cigarettes, those who took the semaglutide have seen a greater decline in the average number of cigarettes they smoked every day.
However, there are a number of questions about semaglutide and alcohol – including whether the drug can be safe and effective for people who have alcohol use but not obesity or diabetes.
Doctors often call drugs like the ozemEmpic “Forever drugs.”“Because they stop working if someone stops taking them. It is not yet clear whether someone with a disorder of alcohol use would have to take medication for the rest of their lives – or what would happen to their desire to get out of the medicine.
And “No one does the drug works for all,” Dr. Simmons. Larger studies may show that some patients with alcohol use for drugs are better responding than others, he said.
Dr. Simmons, along with Dr. Hendershot, Dr. Schacht and other scientists warned In a scientific journal That there is not enough data for the prescribed medicine for alcohol use disorder.
“I’m optimistic, don’t understand me wrong,” Dr. Simmons. “But I just don’t feel comfortable saying that patients should look for these drugs for addiction.”
